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The authors study two interventions in Beijing, China, that provide patients with information on antibiotic resistance via text message to discourage the overuse of antibiotics. The messages were sent once a month for five months. One intervention emphasizes the threat to the recipient's own health and is found to have negligible effects. The other intervention, which highlights the overall threat to society, reduces antibiotics purchases by 17% in dosage without discouraging healthcare visits and other medicine purchases. The results demonstrate that prosocial messaging can have the potential to address public health issues that require collective action.

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Experimental Evidence Based on Antibiotics Purchases

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Journal of Development Economics
Authors
Jianan Yang
Authors
Noa Ronkin
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News
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Do increases in medical spending improve health outcomes? To answer this question, analysts need to quantify the net value of medical spending and measure the productivity of medical care with the output of improvement in survival and quality of life, thereby deducing for what medical conditions the “bang for the buck” is greatest and for what conditions spending outstrips gains in health improvement.

This condition-specific, quality-adjusted net value approach to health spending is known as a “satellite account for health” because it “orbits around” the national income and product accounts that include aggregate health spending to provide a clearer picture of productivity in the health sector. Thus far, researchers have applied this account to the U.S. health sector only, but it would be highly beneficial for many economies. One notable beneficiary would be South Korea, one of the most rapidly aging societies globally. Now new research by Karen Eggleston, the director of APARC’s Asia Health Policy Program, studies the link between medical spending and health outcomes in South Korea, providing evidence on the productivity of medical spending over recent decades.

The research, published by the East-West Center, develops an estimate of the net value of Korean medical spending, which has outpaced most other countries in recent decades. To generate this estimate, Eggleston compares the gains in life expectancy at birth to the increases in medical spending for 2000–2019. Data comes from Korean lifetables and medical expenditures per capita, available from the Korean Statistical Information Services.


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Korea can develop an accurate measure of medical productivity and a more accurate measure of overall economic productivity while becoming a global pioneer of “health satellite accounts” for overall populations.
Karen Eggleston

Eggleston shows that, even with the most conservative assumptions ($50,000 per life-year and only 10 percent of health gains due to medical care), the net value of Korean medical spending is positive and substantial. Korean life expectancy at birth increased from 76 in 2000 to 83.3 in 2019, while lifetime medical spending increased by over $19,000. The value of 7.3 additional years of life far outweighs even this rapid increase in spending, implying substantial productivity growth in Korea’s health sector.

Moreover, evidence on condition-specific spending changes and health improvements suggests that Korea’s rapid spending increases yield significant net value. Eggleston’s research indicates that improvements in survival for key conditions afflicting Koreans, such as stroke and cancer, point to productivity gains. “Korea could be a pioneer in developing a national health account that accurately measures net value by medical condition,” she writes.

Condition-specific metrics of health gain per won spent on treatment can help to guide the allocation of investments to promote longer, healthier lives. In the future, analysts could also link condition-specific improvements in survival and morbidity to earnings. Such linkage would particularly benefit South Korea, where focusing on the productivity of older adult employment is crucial given its high labor force participation and relatively low income of older Koreans.

Eggleston advocates for the Korean government to develop a national satellite account for health that can provide valuable evidence for prioritizing investments to address the country’s most pressing health challenges so that productivity improvement will contribute to longer, healthier lives. “By linking National Health Insurance and health outcome data, Korea could develop an accurate measure of medical productivity and a more accurate measure of overall economic productivity, while pioneering development of ‘health satellite accounts’ for overall populations,” Eggleston argues.

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New Study Shows Health and Economic Benefits of Controlling Diabetes Risk Factors in Chinese Adults

Using recent data from the China Chronic Disease and Nutrition Surveillance survey and applying the Chinese Hong Kong Integrated Modelling and Evaluation microsimulation model, a new study co-authored by APARC's Karen Eggleston found that substantial health improvements and medical savings could be achieved in China by better control of glycemia and blood pressure, two modifiable risk factors for diabetes.
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Most Japanese Support Same-Sex Marriage, New Public Opinion Survey Finds

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A figure dressed as a medical personnel holding a stethoscope and a blurry image of the South Korean flag in the background. Marco Verch via Flickr
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Research by Stanford health economist Karen Eggleston, the director of APARC's Asia Health Policy Program, offers evidence on the link between medical spending and health outcomes in South Korea, showing how the country can benefit from developing a “satellite account for health” to promote high-value innovations for longer, healthier lives.

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Objective

Given the importance of continuous family physician (FP) care in the management of hypertension, we explored the effects of such care among hypertensive patients in China, a country where such care is generally underutilized. We examined the longitudinal association between the use and continuity of FP services and health outcomes including blood pressure (BP) control rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP).

Methods

We conducted a population-based cohort study using data from the retrospective regional electronic health record database in Xiamen City, China. The study considered 18,119 hypertensive patients aged over 18 years who had at least two visits to a health center in the preceding 12 months. The generalized estimating equation model was adopted to estimate the longitudinal association between FP service utilization and health outcomes.

Results

Hypertensive patients treated by their own FPs had a higher BP control rate (OR = 1.14, 95% CI: 1.02–1.28) and lower DBP (−0.36 mmHg, 95% CI: −0.52 to −0.20) than those without a FP or those with a FP but treated by a general community physician (GCP). Compared with hypertensive patients treated exclusively by GCPs, patients treated continuously and exclusively by a FP were 45% more likely to have their BP under control (OR = 1.45, 95% CI: 1.32–1.60), and their SBP and DBP were lower by 0.6 mmHg (95% CI: −0.78 to −0.39) and 0.6 mmHg (95% CI: −0.79 to −0.47), respectively.

Conclusions

Hypertensive patients continuously treated by their own FPs performed better in terms of BP control rate, SBP and DBP values. In addition, the number and continuity of FP visits were associated with better BP control.

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A Population-Based Retrospective Cohort Study

Journal Publisher
Journal of Health Services Research & Policy
Authors
Karen Eggleston
Authors
George Krompacky
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News
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The incidence of diabetes has risen sharply in China from 1% in 1980 to 12.8% in 2017, and it is expected to continue to rise, despite the disease being one of four targeted by the Chinese government in its Healthy China Action Plan 2019-2030. Diabetes takes a high toll, both economically and in terms of healthy years of life. The disease is a major cause of strokes, heart attacks, blindness, and lower limb amputations. Although diabetes is on the rise, treatment and control remain relatively low in China, especially in rural areas.

In a new paper in The Lancet Regional Health—Western Pacific, a research team, which included APARC's Asia Health Policy Program Director Karen Eggleston, examined how improved control of glycemia and blood pressure, two modifiable risk factors for diabetes, could improve health outcomes in China. They performed a microsimulation analysis of more than 20,000 Chinese adults with diabetes, with data taken from the China Chronic Disease and Nutrition Surveillance survey (CCDNS), looking at the increased control of glycemia and blood pressure in 31 different scenarios.


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Similar studies had previously relied upon simulated risk factor levels that did not accurately reflect a representative Chinese population or used non-Asian models that have been known to over-predict medical complications in Chinese populations. The CCDNS data the authors used in their study was collected in 2018-19 from national disease surveillance points in mainland China, and their microsimulation used the CHIME (Chinese Hong Kong Integrated Modelling and Evaluation) model, which has been validated in East Asian populations.

Based on the CCDNS data, only one in five (20.1%) of people with diabetes in China had achieved optimal control of both glycemia and blood pressure in 2018-19. The study modeled control rates of 70%, 80%, and 100% to see the effects on the population’s health. The authors found that control of the two risk factors in people with type 2 diabetes was associated with considerable improvement in health, a reduced number of early deaths, and savings in medical costs. For example, if China were to achieve 70% control of these risk factors (based on current WHO/Chinese Diabetes Society targets for blood glucose and blood pressure), deaths before age 70 could be cut by 7.1% and medical costs by 14.9% over the next 10 years.

The study provides more impetus for China to reach its control targets outlined in the Healthy China plan, which aims for the nation to reach by 2030 health indicator performance comparable to high-income countries like the United States. The authors demonstrate that the health and economic burdens associated with diabetes can be substantially reduced or avoided if glycemia and blood pressure are better regulated in the Chinese population.

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Karen Eggleston

Senior Fellow at the Freeman Spogli Institute for International Studies and Director of the Asia Health Policy Program
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Using recent data from the China Chronic Disease and Nutrition Surveillance survey and applying the Chinese Hong Kong Integrated Modelling and Evaluation microsimulation model, a new study co-authored by APARC's Karen Eggleston found that substantial health improvements and medical savings could be achieved in China by better control of glycemia and blood pressure, two modifiable risk factors for diabetes.

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Background

The prevalence of diabetes has risen sharply in China. Improving modifiable risk factors such as glycaemia and blood pressure could substantially reduce disease burden and treatment costs to achieve a healthier China by 2030.

Methods

We used a nationally representative population-based survey of adults with diabetes in 31 provinces in mainland China to assess the prevalence of risk factor control. We adopted a microsimulation approach to estimate the impact of improved control of blood pressure and glycaemia on mortality, quality-adjusted life-years (QALYs), and healthcare cost. We applied the validated CHIME diabetes outcomes model over a 10-year time horizon. Baseline scenario of status quo was evaluated against alternative strategies based on World Health Organization and Chinese Diabetes Society guidelines.

Findings

Among 24,319 survey participants with diabetes (age 30–70), 69.1% (95% CI: 67.7–70.5) achieved optimal diabetes control (HbA1c <7% [53 mmol/mol]), 27.7% [26.1–29.3] achieved blood pressure control (<130/80 mmHg) and 20.1% (18.6–21.6) achieved both targets. Achieving 70% control rate for people with diabetes could reduce deaths before age 70 by 7.1% (5.7–8.7), reduce medical costs by 14.9% (12.3–18.0), and gain 50.4 QALYs (44.8–56.0) per 1000 people over 10 years compared to the baseline status quo. The largest health gains were for strategies including strict blood pressure control of 130/80 mmHg, particularly in rural areas.

Interpretation

Based on a nationally representative survey, few adults with diabetes in China achieved optimal control of glycaemia and blood pressure. Substantial health gains and economic savings are potentially achievable with better risk factor control especially in rural settings.

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A Microsimulation Modelling Study

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The Lancet Regional Health - Western Pacific
Authors
Karen Eggleston
Number
100690
Authors
Noa Ronkin
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News
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The Walter H. Shorenstein Asia-Pacific Research Center (APARC) is pleased to invite applications for a suite of fellowships in contemporary Asia studies to begin fall quarter 2023.

The Center offers postdoctoral fellowships that promote multidisciplinary research on contemporary Japan and contemporary Asia broadly defined, inaugural postdoctoral fellowships and visiting scholar positions as part of the newly launched Stanford Next Asia Policy Lab, and a fellowship for experts on Southeast Asia. Learn more about each opportunity and its eligibility and specific application requirements:

Postdoctoral Fellowship on Contemporary Japan

Hosted by the Japan Program at APARC, the fellowship supports research on contemporary Japan in a broad range of disciplines including political science, economics, sociology, law, policy studies, and international relations. Appointments are for one year beginning in fall quarter 2023. The application deadline is December 1, 2022.
 

Shorenstein Postdoctoral Fellowship on Contemporary Asia

APARC offers two postdoctoral fellowship positions to junior scholars for research and writing on contemporary Asia. The primary research areas focus on political, economic, or social change in the Asia-Pacific region (including Northeast, Southeast, and South Asia), or international relations and international political economy in the region. Appointments are for one year beginning in fall quarter 2023. The application deadline is December 1, 2022.
 

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The Center offers a suite of fellowships for Asia researchers to begin fall quarter 2023. These include postdoctoral fellowships on contemporary Japan and the Asia-Pacific region, inaugural postdoctoral fellowships and visiting scholar positions with the newly launched Stanford Next Asia Policy Lab, and fellowships for experts on Southeast Asia.

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This press release was originally published by the University of Tokyo. It discusses a new study, published by Lancet Public Health and co-authored by researchers from the University of Tokyo along with FSI Senior Fellow Karen Eggleston, director of the Asia Health Policy Program at APARC, and Jay Bhattacharya, Professor of Health Policy and director of the Center for Demography and Economics of Health and Aging at Stanford.


A new detailed microsimulation, using a database of 40 million people, has examined the future of Japan’s aging population up to 2043. It projects that more people will live longer, and that overall years spent living with dementia will decrease. However, the model highlighted the diversity of impacts on different segments of the population, as Japanese women with a less than high school education aged 75 and over may be disproportionately affected by both dementia and frailty. Better understanding where health gaps like this exist can help inform public health planning, to minimize future economic costs and support those most in need.

Taking care of the older members of society is a common concern around the world. Japan is famous for its long-lived residents, the number of which continues to rise. In 2020, almost 30% of the Japanese population was aged 65 years or older, and this age group is not projected to peak until 2034. Caring for people with age-related ailments, such as dementia and frailty, poses a challenge both to individuals and public health care systems.

Microsimulation models, which are computer models that can provide detailed analysis on an individual basis, are currently used to project future population health in some countries, such as the U.K. and the U.S. Professor Hideki Hashimoto and researchers at the University of Tokyo, along with researchers from Stanford University in the U.S., wanted to create a new microsimulation model for Japan, which would take into account more diverse conditions than had been considered before.

“We developed a new Japanese microsimulation model that accounts for 13 chronic conditions (including heart disease, stroke, diabetes, depression and dependency), as well as frailty and dementia,” explained Hashimoto. “Using an ultralarge data system, we were able to ‘follow’ a virtual cohort of more than 40 million people aged 60 and over from 2016 to 2043.”

According to Hashimoto, projections of aging in Japan usually rely on the “average” status of older people and so don’t consider the diversity of the population. “I believe that problems of aging are a matter of health gaps over the course of people’s lives,” he said. “Our projection brings attention to a widening health gap among older people. It highlighted that women with a less than high school education aged 75 or over are more likely to be affected.”

Identifying where health gaps like this exist could be used to better inform public policy, not only about health care but other influential aspects of life. “Japan’s case may suggest that improvement in educational attainment, as well as population health, could be a key to making a healthier and more manageable aging society,” said Hashimoto.

Positively, this study shows hope for a future where many people live longer and more healthy lives. “People might believe that an increase in cases of dementia is inescapable, given population aging. However, in this study we found that in Japan, despite an aging population, the number of people with dementia is expected to decrease over the next two decades,” said Hashimoto. “Population aging does not necessarily mean an increase of social burden for care, but it does bring a diversity of problems that requires careful study and science-based policy attention, to close the health gap.”

Karen Eggleston 4X4

Karen Eggleston

Senior Fellow at FSI and Director of the Asia Health Policy Program, Shorenstein APARC
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Education Level Will Widen Disparity in Health Outcomes of the Future Elderly Population, New Study Projects

In the first study to compare the progression of educational disparities in disability across two rapidly aging Asian societies, APARC coauthors Cynthia Chen and Karen Eggleston project that from 2015 to 2050, elders with high educational attainment will have a lower prevalence of functional disability and chronic conditions compared to elderly with low educational attainment.
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New Cross-Country Study Underscores the Importance of Health Workforce Development and Socioeconomic Factors in Affecting Health Outcomes

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A new microsimulation projects that over the next 20 years, Japanese people will live longer without dementia, but older women with a less than high school education will benefit less than men.

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Background

Dementia and frailty often accompany one another in older age, requiring complex care and resources. Available projections provide little information on their joint impact on future health-care need from different segments of society and the associated costs. Using a newly developed microsimulation model, we forecast this situation in Japan as its population ages and decreases in size.

 

Methods

In this microsimulation modelling study, we built a model that simulates an individual's status transition across 11 chronic diseases (including diabetes, coronary heart disease, and stroke) as well as depression, functional status, and self-reported health, by age, sex, and educational strata (less than high school, high school, and college and higher), on the basis of nationally representative health surveys and existing cohort studies. Using the simulation results, we projected the prevalence of dementia and frailty, life expectancy with these conditions, and the economic cost for formal and informal care over the period 2016–43 in the population of Japan aged 60 years and older.

 

Findings

Between 2016 and 2043, life expectancy at age 65 years will increase from 23·7 years to 24·9 years in women and from 18·7 years to 19·9 years in men. Years spent with dementia will decrease from 4·7 to 3·9 years in women and 2·2 to 1·4 years in men. By contrast, years spent with frailty will increase from 3·7 to 4·0 years for women and 1·9 to 2·1 for men, and across all educational groups. By 2043, approximately 29% of women aged 75 years and older with a less than high school education are estimated to have both dementia and frailty, and so will require complex care. The expected need for health care and formal long-term care is anticipated to reach costs of US$125 billion for dementia and $97 billion for frailty per annum in 2043 for the country.

 

Interpretation

Japan's Government and policy makers should consider the potential social challenges in caring for a sizable population of older people with frailty and dementia, and a widening disparity in the burden of those conditions by sex and by educational status. The future burden of dementia and frailty should be countered not only by curative and preventive technology innovation, but also by social policies to mitigate the health gap.

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A Microsimulation Modelling Study

Journal Publisher
The Lancet Public Health
Authors
Karen Eggleston
Authors
Noa Ronkin
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No health system can function without health workers — nurses, paramedical professionals, medical laboratory technicians, care assistants, and more — who make it possible to deliver health care. This has led the World Health Organization (WHO) to declare “No health without a workforce” as a universal truth. Yet relatively few studies have analyzed the relationship between health workforce and health outcomes, and some such cross-country and within-country studies show inconsistent results.

A new study published in the journal Social Indicators Research addresses this gap by investigating the strength and significance of the associations of the health workforce with multiple health outcomes and COVID-19 excess deaths across countries. The coauthors of the study — Karen Eggleston, APARC Asia Health Policy Program Director and FSI Senior Fellow, and Jinlin Liu, a professor at China’s Northwestern Polytechnical University’s School of Public Policy and Administration and a 2019-20 visiting scholar at APARC — find that higher density of the health workforce was significantly associated with better levels of multiple health outcomes and with a lower level of COVID-19 excess deaths per 100,000 people.

The study also confirms the pivotal role of socioeconomic factors in affecting health outcomes and underscores the wide disparities in health outcomes across countries in different income categories. In light of the strains on the health workforce during the coronavirus pandemic, this research also emphasizes the importance of investing in the health workforce to strengthen health system resilience and achieve long-term improvement in health outcomes.


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Determining Country-Level Health Outcomes 

Eggleston and Liu investigated how the density of skilled health workers — medical doctors and nursing and midwifery personnel for each country — affected six measures of health outcomes. These measures included maternal mortality ratio, under-five mortality rate, and neonatal mortality rate — all of which are health-related Sustainable Development Goals (SDG) indicators — plus healthy life expectancy at birth, the mortality rate of teens and adults aged 15−60, and infant mortality rate. The researchers also examined COVID-19 excess deaths per 100,000 people as a health outcome measure proxying for the health impact of the coronavirus pandemic.

Additionally, Eggleston and Liu collected and analyzed data on four measures to account for country-level socioeconomic factors pertinent to determining health outcomes. These explanatory variables included health spending per capita, gross national income per capita, poverty headcount ratio, and the mean years of female schooling as a proxy for female educational attainment. They used the latest WHO dataset on the global health workforce, covering 191 WHO member countries.

Our results underscore the importance of accounting for poverty and the broader social determinants of health when studying the association of health outcomes with the health workforce, and the distinction between cross-individual and cross-country disparities.
Karen Eggleston & Jinlin Liu

The researchers found that countries with a higher density of skilled health workers could expect to have better health outcomes across all six measures of health outcomes. Unsurprisingly, high-income countries generally enjoy a high density of skilled health workers and world-leading health outcomes, whereas low-income countries suffer from a shortage of health workers and poor health outcomes. A higher density of skilled health workers was also significantly correlated with a lower level of COVID-19 excess deaths per 100,000 people, highlighting the importance of the health workforce under the pandemic.

A Cause and Effect of Socioeconomic and Health-System Developments

The cross-country results confirm the importance of the health workforce in affecting multiple health outcomes. “Therefore, investment in health workforce should be an integral part of the strategies to improve health outcomes and achieve health-related SDGs for every country, especially for low- and lower-middle-income countries,” write Eggleston and Liu. The vast majority of these countries (about 80%) are tremendously off track to meet the health-related SDGs by 2030.

From a global perspective, the data underscores the wide disparities in health outcomes between different countries, especially between those most and least advantaged (e.g., healthy life expectancy at birth of 44.9 years in the Central African Republic compared with 76.2 years in Singapore).

A strong health workforce contributes to better health outcomes and is itself a manifestation of a country’s previous investments that reduced poverty, improved health outcomes, and laid the foundation for a robust health system.
Karen Eggleston & Jinlin Liu

It is difficult, however, to improve disparities in health outcomes between countries in different income categories by improving the density of the health workforce alone. The reason is that socioeconomic factors, as the data confirms, are critical determinants of health outcomes. For example, higher health expenditure per capita and the poverty headcount ratio have significant associations with all six health outcomes, while female education is interrelated with broader social determinants of health.

Thus, the relationship between the health workforce and health outcomes is the cause and effect of broader socioeconomic and health-system developments. “A strong health workforce contributes to better health outcomes and is itself a manifestation of a country’s previous investments that reduced poverty, improved health outcomes, and laid the foundation for a robust health system,” Eggleston and Liu explain.

Investment in the health workforce is an urgent task, the researchers conclude. It should be an integral part of strategies to achieve health-related SDGs, and these strategies, in turn, should include means to achieving complementary non-health SDGs related to poverty alleviation and expansion of female education.

Karen Eggleston 4X4

Karen Eggleston

Senior Fellow at the Freeman Spogli Institute for International Studies and Director of the Asia Health Policy Program, Shorenstein APARC
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A health clinic in Pokhara, Nepal.
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Analyzing data from 191 World Health Organization member countries, a new study from APARC’s Karen Eggleston indicates that strengthening the health workforce is an urgent task in the post-COVID era critical to achieving health-related Sustainable Development Goals and long-term improvement in health outcomes, especially for low- and lower-middle-income countries.

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Cover of the journal Social Indicators Research
This study investigates the strength and significance of the associations of health workforce with multiple health outcomes and COVID-19 excess deaths across countries, using the latest WHO dataset.

Multiple log-linear regression analyses, counterfactual scenarios analyses, and Pearson correlation analyses were performed. The average density of health workforce and the average levels of health outcomes were strongly associated with country income level. A higher density of the health workforce, especially the aggregate density of skilled health workers and density of nursing and midwifery personnel, was significantly associated with better levels of several health outcomes, including maternal mortality ratio, under-five mortality rate, infant mortality rate, and neonatal mortality rate, and was significantly correlated with a lower level of COVID-19 excess deaths per 100K people, though not robust to weighting by population.

The low density of the health workforce, especially in relatively low-income countries, can be a major barrier to improving these health outcomes and achieving health-related Sustainable Development Goals (SDGs); however, improving the density of the health workforce alone is far from enough to achieve these goals. Our study suggests that investment in health workforce should be an integral part of strategies to achieve health-related SDGs, and that achieving non-health SDGs related to poverty alleviation and expansion of female education are complementary to achieving both sets of goals, especially for those low- and middle-income countries. In light of the strains on the health workforce during the current COVID-19 pandemic, more attention should be paid to health workforce to strengthen health system resilience and long-term improvement in health outcomes.

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Karen Eggleston
Jinlin Liu
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