Research Presentations (1 of 3) - Aosaki, Pandya and Ramanathan
In this session of the Shorenstein APARC Corporate Affiliate Visiting Fellows Research Presentations, the following will be presented:
Minoru Aosaki, "Banking System and Sovereign Risk in Japan"
After the financial crisis of 2008, European financial markets have experienced sharp increases of sovereign risk. This adversely affected the solvency of banking institutions as they suffered losses from their sovereign holdings and deterioration in their funding conditions. Meanwhile, Japan's sovereign market remained stable, but market participants were cautious as the country’s debt-to-GDP ratio is the highest in the world, and its banking sector holds as much as 44% of domestic sovereign debt. The question is how Japanese policy makers should address the sovereign risk in the banking system. In pursuit of this question, Aosaki compares the market environment in Japan and the Euro Area, examining the reasons banks hold sovereign bonds and the channels that connect sovereign risk with the banking system.
Prashant Pandya, "Cell-based Therapies -- Current Trends and Future Prospects"
Stem cells have been the subject of considerable excitement and debate over the last decade. Stem cell therapy is emerging as a potentially revolutionary new way to treat disease and injury, with wide-ranging medical benefits. Stem cell research provides the opportunity to advance our understanding of human biology and treatment of various diseases. In Pandya’s research, he shares his experience about major challenges related to the commercial development of stem cell therapies and key technology drivers. This research is based on consultations with several prestigious regulatory agencies—including the U.S. Food and Drug Administration, European Medicines Agency, and Therapeutic Goods Administration of Australia—as well as interviews with 45 CEOs and senior scientists of large and small biotech companies and professors from leading universities across five countries. Pandya’s research reveals that there are many intriguing aspects of stem cells still remaining to be elucidated. Stem cells have the potential to treat an enormous range of diseases and conditions that plague millions of people and offer exciting promise for future therapies. But significant technical hurdles remain that will only be overcome through years of intensive research, and successful commercialization of cell-based therapies requires more than proving safety and efficacy to regulators. Ultimately the therapy must be commercially viable.
Ramnath Ramanathan, "Designing Toxicology Studies for Small Interfering Ribo Nucleic Acid"
The field of medicine has improved drastically over the period of time. Medical treatment has evolved from using plant extracts to chemical drugs to stem cell and gene therapies. Discovery of small interfering Ribo Nucleic Acid (siRNA) was one of the most important recent breakthroughs in the field of medicine. This was due to siRNA’s capability of posttranscriptional gene silencing by destruction of mRNA and thereby reducing the protein synthesis. Though the efficacy studies conducted in vitro and in animal models are promising, there have also been circumstances where there were adverse effects including mortality of animals treated with siRNA. Since RNA interference is a relatively new technique, it is very important to understand the toxicity involved before using it as a therapy. For this purpose, toxicology studies have to be designed in order to address all questions on the safety aspects of siRNA. In addition to the traditional toxicity studies, several other tests will have to be conducted. These additional studies will have to address issues specific to siRNA therapy such as immune activation, formation of tetraplex DNA, down regulation of non-target mRNA, interaction with cellular proteins, etc. Through Ramanathan’s work, he has designed a battery of toxicology studies to understand the side effects so that only relatively safe therapy is tried on humans during clinical trials. Ramanathan will present his findings.
Philippines Conference Room
Minoru Aosaki
Minoru Aosaki is a corporate affiliate visiting fellow at the Walter H. Shorenstein Asia-Pacific Research Center (Shorenstein APARC) for 2010–11 and 2011–12. Prior to joining Shorenstein APARC, he was deputy director for international banking regulations at the Government of Japan's Financial Services Agency, where he was responsible for developing bank regulatory standards as a member of groups of the Basel Committee on Banking Supervision. Before 2008, he worked for Japan's Ministry of Finance and drafted the ministry's policy-position papers on the International Monetary Fund and also participated in the communiqué drafting processes at the G7 and G20 meetings.
During his time at Shorenstein APARC, Aosaki researches policy responses to the recent financial crisis with the support of Dr. Michael Armacost, and discussed at seminars and conferences at Stanford University, Cornell University, and Harvard University. He received a bachelor of law degree (LL.B.) from Hitotsubashi University in 2001, a master of public administration degree (MPA) from Syracuse University in 2004, and a master of law degree (LL.M.) from Cornell Law School in 2005.
Prashant Pandya
Prashant Pandya is a corporate affiliate visiting fellow at Shorenstein APARC for 2011-12. Prior to joining Shorenstein APARC, he has worked for Reliance Life Sciences at Navi Mumbai (India) as a Deputy General Manager.
He has over 12 years of experience in various fields such as first in human studies, stem cell research, phase-II-IV, bioequivalence and QTC studies. He has monitored and conducted more then 100 national and global studies and has hands-on experience in the complete drug development process. He is a qualified Pharmacist, certified Project Manager & clinical research professional with post-graduate work in pharmaceutical & business management. Prior to joining Reliance Life Sciences, he was associated with India’s leading pharmaceutical and Contract Research Organizations such as Ranbaxy & Cadila.
Ramnath Ramanathan
Ramnath Ramanathan is a corporate affiliate visiting fellow at Shorenstein APARC for 2011-12. He works for Reliance Life Sciences Pvt. Ltd. (India). For more than 6 years with Reliance, he has been working on various branches of laboratory animal research. He started his carrier with monitoring quality of laboratory animals. Currently, his major field of work is toxicology. His interests include creation and research on animal models of human diseases.
Ramanathan received his Masters degree in biotechnology from the Univeristy of Madras and is currently pursuing his Ph.D. in biochemistry at Mumbai University.