Pradnya Palande's passion for improving human health through scientific research began during her graduate studies, and has continued to the present day through her work with Reliance Life Sciences (RLS) of India. Palande, a 2010-2011 Corporate Affiliates Fellow, holds a master's degree in zoology, with a specialization in animal physiology and a minor in biotechnology. "I used to dream of getting a job in the biotechnology industry," she says. Within just a few short months of graduating, Palande began working for RLS, and she has enjoyed serving the company for the past nine years.

RLS belongs to the Reliance Group, one of India's largest corporate entities. It conducts research in a wide variety of areas, such as stem cell therapy, molecular medicine, and industrial biotechnology, and it offers products ranging from therapeutic proteins to tissue-cultured plants. "RLS is a life sciences company in the truest sense," Palande states. In her role as a team leader for the company's biopharmaceuticals division, which is headed by Dr. Venkata Ramana, she conducts literature searches and strategic planning for new research projects, and also supports regulatory audits. In addition to her primary duties, Palande is dedicated to her role as secretary of the safety observation committee. "RLS believes in safety and a safe working culture," Palande emphasizes. "It is a perfect place for me to work."

During her year at the Walter H. Shorenstein Asia-Pacific Research Center (Shorenstein APARC), Palande is conducting cancer-related research in a laboratory under the direction of Cliff L. Wang of the Department of Chemical Engineering. Her Shorenstein APARC advisors are Rafiq Dossani, a senior research scholar, and Karen Eggleston, the director of the Asia Health Policy Program. Palande and her fellow researchers in Wang's lab are studying the population dynamics of cancer cells. In the process of cancer development, Palande explains, it is thought that cells often develop high mutational activity before accumulating mutations that lead to cancer. Mutations—changes in the genome sequence—can be advantageous, benign, or harmful to cells. Palande is examining whether a high mutation rate provides a survival advantage to cancer cells. For this, she is studying the activation-induced cytidine deaminase (AID) enzyme, which plays a key role in the development of immune response in the human body. The goal of the project is to provide insight into the nature of cancer development, and also to give direction for the prevention of chemotherapy resistance due to AID activity.

"Before I leave for India, I would like to complete my project successfully in a way that will instigate future research in cancer biology," Palande says. Upon returning to RLS, she intends to apply some of the concepts that she has gained while conducting research at Stanford. She also hopes to build upon the Stanford management classes that she has been auditing, studying the subject in more detail with the intention of utilizing it in her work at RLS.

"It has been a great privilege for me to work at Stanford, and it has been an amazing experience," she states. "Interacting with people from various backgrounds has been enlightening. Also, I am quite impressed by the professionalism of people [in the United States], their helping nature, and their free way of life. I love it." She adds that through her Stanford research and classes, her horizons have been broadened.

As passionate about the natural world as she is about scientific research, Palande looks forward to traveling more before returning to India. "I love traveling to be close to nature," she says. Also something of an adventurer, she has taken a rock-climbing course and has tried skydiving. Inspired by the range of activities in the United States, she plans to take an activity class, such as dance, after returning to India. "I want to keep myself as active and healthy as possible," she says with a smile.

A group of leading American and Japanese venture capitalists, entrepreneurs, academic experts, government officials, and leaders in business and related fields joined the "U.S. - Japan Dialogue to Promote Innovation, Entrepreneurship and Job Creation" symposium, organized by the Stanford Project on Japanese Entrepreneurship (STAJE), the largest U.S.-Japan event held at Stanford in many years, on February 23, 2011.

Representatives from both governments opened the event by underscoring the economic and strategic reasons for closer U.S.-Japan cooperation in promoting innovation and entrepreneurship. U.S. Ambassador to Japan John V. Roos emphasized how an economically vibrant Japan is critical to the security of the United States, and how it creates opportunities for U.S. trade, investment, and job creation. Moreover, innovation and collaboration are vital to addressing critical global issues, such as climate change. Under Secretary of State Robert D. Hormats noted how innovation and entrepreneurship, often involving young firms bringing new technology to market, are fundamental to ensuring sustainable growth and inclusive prosperity, both at home and across the globe. For Japan, Teruhiko Mashiko, a Ranking Member of the Diet's Committee on Economy and Industry and a former Senior Vice Minister of Economy, Trade, and Industry, highlighted the potential for greater employment, development of green technology, and the circulation of human and other resources through innovation and entrepreneurship.

Several speakers pointed to ways government and the private sector can foster the creation of entrepreneurial ventures with a global outlook. Professor William F. Miller, co-director of the Stanford Program on Regions of Innovation and Entrepreneurship (SPRIE), focused attention on the need to support the full entrepreneurial habitat—including an active angel investor and venture community, entrepreneurial education, passionate entrepreneurs, and business services (legal, consulting, financial) that understand the needs of start-up companies. Additionally, several speakers suggested that mid-career hiring by large Japanese firms and greater willingness on their part to grow by acquisition would increase labor mobility and expand opportunities for entrepreneurial ventures. They expressed concern that, at present, a public offering of shares is practically the only option for startup firms to exit the venture stage in Japan. Others highlighted how greater English-language proficiency and changes in immigration law could expand the linkages between Japan and the global community of entrepreneurs and venture capitalists.

Larry W. Sonsini, Chairman of Wilson Sonsini Goodrich & Rosati, reflected on the waves of innovation that Silicon Valley has generated, both in terms of new technologies coming to market as well as the maturing of technology already out. Defining Silicon Valley as a culture rather than a place, he outlined the ingredients in the recipe for its success: an entrepreneurial culture, with such features as mobility of talent, diversity, and acceptance of failure as a type of learning; ready access to capital; sources of technology and technologists, particularly from universities and large forward-looking corporations; government support; developed laws and accounting systems; availability of exit options for ventures; and an infrastructure of lawyers, accountants, bankers, and consultants. He also offered his thoughts on key trends that will influence the position and direction of emerging technology companies, including: globalization, regulatory changes, development of capital markets, education, and the rule of law.

In the closing remarks of the day-long symposium, Robert Eberhart, a SPRIE researcher and the leader of the SPRIE-STAJE project, summarized the three potential roles for governments to play in promoting innovation and entrepreneurship: to establish rules to ensure fair dealing and access to the market; to rewrite (i.e., reform) the rules of a market thereby ensuring firms will address it in new ways; and to stimulate demand for advanced technology by purchasing it for its own reasons, thereby creating new opportunities for entrepreneurial technology ventures.