Pradnya Palande discusses Reliance Life Sciences and Stanford cancer research

PalandeNEWSFEED Pradnya Palande, 2010-2011 Corporate Affiliates Fellow

Pradnya Palande's passion for improving human health through scientific research began during her graduate studies, and has continued to the present day through her work with Reliance Life Sciences (RLS) of India. Palande, a 2010-2011 Corporate Affiliates Fellow, holds a master's degree in zoology, with a specialization in animal physiology and a minor in biotechnology. "I used to dream of getting a job in the biotechnology industry," she says. Within just a few short months of graduating, Palande began working for RLS, and she has enjoyed serving the company for the past nine years.

RLS belongs to the Reliance Group, one of India's largest corporate entities. It conducts research in a wide variety of areas, such as stem cell therapy, molecular medicine, and industrial biotechnology, and it offers products ranging from therapeutic proteins to tissue-cultured plants. "RLS is a life sciences company in the truest sense," Palande states. In her role as a team leader for the company's biopharmaceuticals division, which is headed by Dr. Venkata Ramana, she conducts literature searches and strategic planning for new research projects, and also supports regulatory audits. In addition to her primary duties, Palande is dedicated to her role as secretary of the safety observation committee. "RLS believes in safety and a safe working culture," Palande emphasizes. "It is a perfect place for me to work."

During her year at the Walter H. Shorenstein Asia-Pacific Research Center (Shorenstein APARC), Palande is conducting cancer-related research in a laboratory under the direction of Cliff L. Wang of the Department of Chemical Engineering. Her Shorenstein APARC advisors are Rafiq Dossani, a senior research scholar, and Karen Eggleston, the director of the Asia Health Policy Program. Palande and her fellow researchers in Wang's lab are studying the population dynamics of cancer cells. In the process of cancer development, Palande explains, it is thought that cells often develop high mutational activity before accumulating mutations that lead to cancer. Mutations—changes in the genome sequence—can be advantageous, benign, or harmful to cells. Palande is examining whether a high mutation rate provides a survival advantage to cancer cells. For this, she is studying the activation-induced cytidine deaminase (AID) enzyme, which plays a key role in the development of immune response in the human body. The goal of the project is to provide insight into the nature of cancer development, and also to give direction for the prevention of chemotherapy resistance due to AID activity.

"Before I leave for India, I would like to complete my project successfully in a way that will instigate future research in cancer biology," Palande says. Upon returning to RLS, she intends to apply some of the concepts that she has gained while conducting research at Stanford. She also hopes to build upon the Stanford management classes that she has been auditing, studying the subject in more detail with the intention of utilizing it in her work at RLS.

"It has been a great privilege for me to work at Stanford, and it has been an amazing experience," she states. "Interacting with people from various backgrounds has been enlightening. Also, I am quite impressed by the professionalism of people [in the United States], their helping nature, and their free way of life. I love it." She adds that through her Stanford research and classes, her horizons have been broadened.

As passionate about the natural world as she is about scientific research, Palande looks forward to traveling more before returning to India. "I love traveling to be close to nature," she says. Also something of an adventurer, she has taken a rock-climbing course and has tried skydiving. Inspired by the range of activities in the United States, she plans to take an activity class, such as dance, after returning to India. "I want to keep myself as active and healthy as possible," she says with a smile.